Effect of Citric Acid Concentration on the Physicochemical Properties and Release Profile of Ibuprofen-loaded Digitaria exilis Starch Nanoparticles

Abstract

Nanoparticulate drug delivery systems (NPDDS) have been exploited to overcome the limitations of oral drug delivery. This study evaluated the physicochemical properties of starch citrate and release profile of Ibuprofen from Digitaria exilis starch nanoparticles prepared by the nanoprecipitation method in the presence of Tween80. Nanoparticles were obtained by preparing starch citrate at different concentrations (10 %, 20 % and 30 %) using citric acid, it was dissolved in sodium hydroxide solution (30 % w/w) and precipitated with absolute ethanol. Physicochemical characterization of native and cross-linked Digitaria exilis starch were undertaken, including FTIR, DSC and XRD. The Encapsulation efficiency, loading capacity, particle size, polydispersity index, SEM, in-vitro release and release kinetics of the nanoparticles were also undertaken. Results show that cross-linking significantly influenced the physicochemical properties of native starch. FTIR reveals an introduction of a C=O group at 20 % concentration of CA, which produced particles in the nanometre range (933 nm), with a smooth and spherical structure revealed by SEM.  The cross-linked nanoparticles at 20 % showed a controlled release, with the highest cumulative drug release of 40.44 % in 24 h. Citric acid cross-linked D. exilis starch can be utilized as a cost-effective vehicle for the sustained delivery of biomolecules.

Keywords

Citric Acid, starch, Digitaria exilis, nanoparticles

How to Cite

John, J. E., Tytler, A. B., Habila, J., Apeji, Y., Isimi, C. Y. & Dada, A., (2023) “Effect of Citric Acid Concentration on the Physicochemical Properties and Release Profile of Ibuprofen-loaded Digitaria exilis Starch Nanoparticles”, British Journal of Pharmacy 8(1). doi: https://doi.org/10.5920/bjpharm.1010

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Authors

Judith Eloyi John (National Institute for Pharmaceutical Research and Development (NIPRD))
Akinyele Babajide Tytler orcid logo (Ahmadu Bello University, Zaria, Nigeria.)
James Habila orcid logo (Ahmadu Bello University, Zaria)
Yonni Apeji orcid logo
Christiana Yetunde Isimi orcid logo (National Institute for Pharmaceutical Research and Development (NIPRD))
Adeniyi Dada orcid logo (National Institute for Pharmaceutical Research and Development (NIPRD))

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This article has been peer reviewed.

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