Dansyl linked solid phase resins as an educational tool to teach the concepts of high throughput screening and prodrugs.

Abstract

High throughput screening (HTS) and combinatorial chemistry, have been part of the process of drug design for nearly two decades. However, methods to teach their practical aspects to undergraduate students are scarce in the literature. The authors describe the synthesis and reactivity, under hydrolytic and transesterification conditions, of newly prepared fluorescent solid phase resins, envisaged to teach the concept of HTS, and prodrugs, to undergraduate students. Although the enzymatic methods did not perform well, the chemical hydrolysis, and the transesterification reaction, of these new solid phase resins, worked in very good yields, and produced very useful results. In relation to the experiment, the student’s learning experience, and feedback, were very positive.

Keywords

Undergraduate student practical, high throughput screening, chemical education, prodrugs

How to Cite

Morral, J., Ibrahim, A., Traore, F. & Pors, K., (2023) “Dansyl linked solid phase resins as an educational tool to teach the concepts of high throughput screening and prodrugs.”, British Journal of Pharmacy 8(1). doi: https://doi.org/10.5920/bjpharm.1045

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Authors

Jordi Morral (Triaca)
Ali Ibrahim (University of Bradford)
Fatima Traore (University of Huddersfield)
Klaus Pors (University of Bradford)

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Creative Commons Attribution 4.0

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This article has been peer reviewed.

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