Antimicrobial cationic surfactant-loaded hydrogel coatings in preventing medical device-associated infections
Rapid Communication
Antimicrobial cationic surfactant-loaded hydrogel coatings in preventing medical device-associated infections
Rapid Communication
Antimicrobial cationic surfactant-loaded hydrogel coatings in preventing medical device-associated infections

Abstract

Hydrogels described herein were developed as anti-microbial coating materials. Three different hydrogels, p(HEMA), p(85%HEMA-co-15% MMA), and p(85% HEMA-co-15% MAA) were loaded with two cationic surfactants, BAK, and DDAB, respectively. DDAB owned better effectivity than BAK in killing S. aureus and E. coli. Compared to unmodified(HEMA), all drug-loaded samples exhibited significant anti-adherence ability against E. coli, but on surfaces of all DDAB-loaded hydrogels, bacteria were below the limit of detection, so DDAB was more effective than BAK in conferring anti-adherent properties.

Keywords

MDAIs, hydrogel, cationic surfactants, anti-adherence.

How to Cite

Teng, X., Clerkin, C. G. & McCoy, C. P., (2022) “Antimicrobial cationic surfactant-loaded hydrogel coatings in preventing medical device-associated infections”, British Journal of Pharmacy 7(2). doi: https://doi.org/10.5920/bjpharm.1078

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Authors

Xiao Teng (Queen's University Belfast)
Caoimhe G Clerkin (Queen's University Belfast)
Colin P McCoy (Queen's University Belfast)

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Dates

Accepted 2022-07-14
Published 2022-11-04

Licence

Creative Commons Attribution 4.0

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This article has been peer reviewed.

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