Exploring drug-surfactant interactions and their impact on the intrinsic surface properties of aqueous dissolution media

Abstract

Surfactants are often used to improve the solubility of a compound for dissolution studies in aqueous media. Having observed non-linear solubility enhancement with increasing surfactant concentration, this study investigated the effect of a poorly soluble, zwitterionic, moderately lipophilic drug, Compound A, on the critical micelle concentration (CMC)of sodium lauryl sulfate (SLS) in phosphate buffer. A force tensiometer was used to measure the surface tension of the solutions over a range of surfactant concentrations. The presence of Compound A demonstrated a decrease in the CMC, suggesting that the solution favours micellisation at lower surfactant concentrations in the presence of the drug. Future studies will use a fully saturated solution of Compound A to explore this observation further. Additional experiments will also investigate micelle formation of SLS with other compounds.

Keywords

critical micelle concentration, dissolution, solubility, surfactant

How to Cite

Greensides, P., McAllister, M., Sarcevica, I. & Tomaszewska, I., (2022) “Exploring drug-surfactant interactions and their impact on the intrinsic surface properties of aqueous dissolution media”, British Journal of Pharmacy 7(2). doi: https://doi.org/10.5920/bjpharm.1081

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Authors

Phoebe Greensides (Pfizer)
Mark McAllister (Pfizer)
Inese Sarcevica (Pfizer)
Irena Tomaszewska (Pfizer)

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Creative Commons Attribution 4.0

Competing Interests

The authors declare no conflicts of interest or competing financial interests.

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This article has been peer reviewed.

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