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Anaesthetic efficacy of intraoral topical lidocaine and prilocaine in nanostrusctured lipid nanocarriers: a randomized clinical trial

Abstract

This randomized placebo-controlled crossover trial evaluated if nanostructured lipid nanocarriers (NLC) could improve the topical anaesthetic efficacy of lidocaine and prilocaine (L+P) incorporated in a xanthan-hydrogel applied in the oral cavity. There were no differences among topical formulations regarding the primary endpoints of pain intensity during needle insertion or local anaesthetic injection. Nonetheless, exploratory analyses indicate that individuals with low mechanical pain sensitivity were more susceptible to placebo effects which could also interfere with the anaesthetic effects of the topical formulations. Thus, mechanical pain sensitivity can be an interesting approach to increase assay sensitivity in clinical trials of topical anaesthesia.

Keywords

topical anaesthesia, dentistry, oral cavity, nanocarrier

How to Cite

Pestana, A. M., Lucas, A. M., Augusto, G. G., Ribeiro, L. N., Costa, Y. M. & Franz-Montan, M., (2022) “Anaesthetic efficacy of intraoral topical lidocaine and prilocaine in nanostrusctured lipid nanocarriers: a randomized clinical trial”, British Journal of Pharmacy 7(2). doi: https://doi.org/10.5920/bjpharm.1082

Funding

Name
Fundação de Amparo à Pesquisa do Estado de São Paulo
FundRef ID
http://dx.doi.org/10.13039/501100001807
Funding ID
2020/03786-9
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Authors

Aylla Mesquita Pestana (Piracicaba Dental School)
Ana Luiza Martins Lucas (Piracicaba Dental School)
Gabriela Gama Xavier Augusto (Piracicaba Dental School)
Lígia Nunes de Morais Ribeiro (Institute of Biotechnology, Federal University of Uberlandia)
Yuri Martins Costa (Piracicaba Dental School, University of Campinas)
Michelle Franz-Montan (University of Campinas)

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Creative Commons Attribution 4.0

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This article has been peer reviewed.

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