Strategies to reduce the wearing time of cabotegravir sodium dissolving microarray pacthes by facilitating fast tip detachment from the baseplate

Abstract

Dissolving microarray patches (DMAP) contain micron-scale projections and are usually made from biocompatible water-soluble polymers containing a high amount of drug in their tips, to be delivered through the skin layers. The challenge regarding DMAP is the detachment of the tips from the baseplate.  This impacts the wearing time, the delivery efficiency of the skin, and patient compliance. In our previous work, we reported the delivery of cabotegravir sodium (CAB Na), an anti-HIV drug, necessitating the wearing time of more than 1 hour [1]. Herein we developed strategies to reduce the wearing time of DMAP containing cabotegravir sodium from hours to 10 minutes by facilitating tip detachment from the baseplate. 

Keywords

wearing time, dissolving microneedles, microarray patches, cabotegravir sodium, HIV, dissolving microarray patches, baseplate, backing layer

How to Cite

Volpe-Zanutto, F., Kumar, L. V., Tekko, I., Jarrahian, C. & Donnelly, R. F., (2022) “Strategies to reduce the wearing time of cabotegravir sodium dissolving microarray pacthes by facilitating fast tip detachment from the baseplate”, British Journal of Pharmacy 7(2). doi: https://doi.org/10.5920/bjpharm.1083

Funding

  • United States Agency for International Development (USAID) through the United States President’s Emergency Plan for AIDS Relief (PEPFAR) (grant #AID-OAA-A-17-00015)
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Authors

Fabiana Volpe-Zanutto (Queens University Belfast)
Lalitkumar V. Kumar (Queens University Belfast)
Ismaiel Tekko orcid logo (Queen's University Belfast)
Courtney Jarrahian (PATH)
Ryan F Donnelly orcid logo (Queen's University Belfast)

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