Abstract
This study investigated the effects of moderately increasing medium viscosity through two viscosity enhancing agents (VEA) (HPMC and sucrose) on the intrinsic dissolution of a BCS class II drug (ibuprofen). The differences in intrinsic dissolution were characterized through the estimation of a diffusion coefficient (D) of ibuprofen in different media with the Levich equation. Increasing viscosity decreased the intrinsic dissolution rate of ibuprofen with both VEAs. The calculated D from intrinsic dissolution data overestimated the experimental value, but the results suggest that intrinsic dissolution could be used as a tool to estimate a relative change in D in different viscosities.
Keywords
dissolution, viscosity, ibuprofen, diffusion
How to Cite
Navas Bachiller, M., Persoons, T., Healy, A. & D'Arcy, D. M., (2022) “Assessing the effect of moderately increasing medium viscosity on the intrinsic dissolution rate and diffusion coefficient of ibuprofen particles”, British Journal of Pharmacy 7(2). doi: https://doi.org/10.5920/bjpharm.1130
Funding
- SFI Manufacturing (grant 12/RC/2275_P2)
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