Evaluating the effects of processing parameters on budesonide nanocrystals prepared by nanomilling

Abstract

The aim of this study was to optimise processing parameters in the preparation of budesonide nanocrystals by a miniature media milling process performed at lab scale. Using Polysorbate 80 as the surfactant choice of stabilizer, the effect of milling bead size, milling time and stabilizer concentration on budesonide particle size was determined. Particle size decreased with smaller milling bead size and longer milling time. However, no significant further decrease was seen after milling past 6 hours. Increasing Polysorbate 80 concentration led to an increase in budesonide particle size. Future direction will incorporate stability study with the screening of optimal stabilizer choice. 

Keywords

Inhaled drug delivery, Nanocrystals, Nanomilling, Budesonide, Pulmonary drug delivery

How to Cite

Olubi, R., Small, W., Burley, J. & Bosquillon, C., (2022) “Evaluating the effects of processing parameters on budesonide nanocrystals prepared by nanomilling”, British Journal of Pharmacy 7(2). doi: https://doi.org/10.5920/bjpharm.1140

Funding

  • EPSRC (grant EP/L01646X/1)
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Authors

Rebecca Olubi (University of Nottingham)
William Small (Croda Europe Ltd)
Jonathan Burley (University of Nottingham)
Cynthia Bosquillon (University of Nottingham)

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Creative Commons Attribution 4.0

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