A Translation of Technology: MicroCoat™ to Sustained Release Orally Disintegrating Tablets

Abstract

Orally disintegrating tablets (ODTs) comprising sustained release (SR) coated microparticles smaller than 250 µm provide an appealing dosage form for patients with dysphagia, offering a superior mouthfeel and highly convenient route of administration without the need for water. SR coating for microparticles of the requisite size(<200 µm) is incredibly challenging however the utilisation of the MicroCoat™ technology, whereby various dry powder glidants are added during SR coating, was demonstrated to achieve desirable coating outcomes. ODTs were prepared via direct compression. In addition to conventional USP methods, texture analysis(TA) was applied to determine disintegration. ODTs were shown to disintegrate within an acceptable time (<30s) and drug release was unaffected by compression during tabletting indicating a robust coating.

Keywords

sustained release; microparticles, coating, dysphagia, sustained release, microparticles

How to Cite

Patel, K., Murnane, D., Richardson, C. & Liu, F., (2022) “A Translation of Technology: MicroCoat™ to Sustained Release Orally Disintegrating Tablets”, British Journal of Pharmacy 7(2). doi: https://doi.org/10.5920/bjpharm.1142

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Authors

Kavil Patel (University of Hertfordshire)
Darragh Murnane (University of Hertfordshire)
Craig Richardson (IP Group PLC)
Fang Liu (University of Hertfordshire)

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