Solubility Enhancement for Dietheyldithiocarbamate-Zinc for Lung Cancer Treatment

Abstract

Diethyldithiocarbamate zinc (Zn(DDC)2), has shown promising antineoplastic effects against a wide variety of cancers. However, this application was hindered by its poor water solubility. Therefore, complexation with cyclodextrin was used to enhance the solubility. Five different concentrations of 2-hydroxyl beta-cyclodextrin (HP) and ether beta-cyclodextrin (SBE) were used. CD-Zn(DDC)2 solutions were freez-dried for further characterisation using DSC, TGA and FT-IR. The phase solubility study showed a significant water-solubility enchantment of  Zn(DDC)2, and the characterisation studies confirmed the formation of inclusion complexes CD-Zn(DDC)2. Overall, CDs have improved Zn(DDC)2 solubility significantly and showed a promising anticancer activity against lung cancer cells. Hence, CD-Zn(DDC)2 complexes have a great potential for further studies against cancer.    

Keywords

Diethyldithiocarbamate-zinc; Cyclodextrins; Solubility; Inclusion complexes; Lung Cancer

How to Cite

Kaya, A., Ansari-Fard, N., Alves, D., Arafat, B., Chichger, H. & Najlah, M., (2022) “Solubility Enhancement for Dietheyldithiocarbamate-Zinc for Lung Cancer Treatment”, British Journal of Pharmacy 7(2). doi: https://doi.org/10.5920/bjpharm.1147

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Authors

Ayse Kaya (Anglia Ruskin University)
Niusha Ansari-Fard (Anglia Ruskin University)
Dan Alves (Anglia Ruskin University)
Basel Arafat (Anglia Ruskin University)
Havovi Chichger (Anglia Ruskin University)
Mohammad Najlah (Anglia Ruskin University)

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