Effect of Precirol ATO5 concentration and twin-screw melt granulation temperature on the physical properties of ascorbic acid granules

Abstract

The pharmaceutical industry has a growing interest in continuous manufacturing, particularly for high-volume dosage forms such as solid oral tablets. This is driven by the obvious benefits such as small footprint, batch size flexibility, the relative simplicity of scale-up and process control. Tablets are the most popular solid dosage form, while batch granulation is one of the most often used technologies in tablet manufacturing. Using ascorbic acid as a model, we show the possibility of producing granules and tablets with a sustained-release profile using three technological operations: mixing, continuous melt-granulation, and tabletting.

Keywords

granulation, melt granulation, twin-screw extrusion, tablets, melt-granulation

How to Cite

Mohylyuk, V., Jones, D., Li, S., Ding, Y. & Andrews, G. P., (2022) “Effect of Precirol ATO5 concentration and twin-screw melt granulation temperature on the physical properties of ascorbic acid granules”, British Journal of Pharmacy 7(2). doi: https://doi.org/10.5920/bjpharm.1160

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Authors

Valentyn Mohylyuk (Queen's University Belfast)
David Jones (Queen's University Belfast)
Shu Li (Queen's University Belfast)
Yalin Ding (Queen's University Belfast)
Gavin Patrick Andrews (Queen's University Belfast)

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Creative Commons Attribution 4.0

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This article has been peer reviewed.

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