The therapeutic efficacy of anticancer nanocarriers is highly dependent on their size, shape, targeting ability, and stimuli-responsiveness. Herein, we studied the in vivo therapeutic efficacy of Doxorubicin (Dox) loaded redox responsive micellar-like nanoparticles (MNPs)based on linear 2-hydroxypropyl methacrylamide (HPMA) via histopathological evaluations. The therapeutic efficacy of DOX-loaded micellar-like Nanoparticles significantly improved while the side effects reduced as confirmed by histopathological examinations. H&E and tunnel staining of tumor tissues indicated the higher population of apoptotic tumor cells in both treatment groups containing DOX. These redox responsive crosslinked HPMA-based micellar-like nanoparticles with acceptable therapeutic efficacy and apoptosis induction in cancerous cells proved to be promising nanomedicine for breast cancer chemotherapy.
Redox-responsive micellar nanoparticles, Histopathology, apoptosis, Triple negative breast cancer
How to Cite
Mehradnia, F. & Moloney, C. & Cavanagh, R. & Pearce, A. K. & Ritchie, A. & Clarke, P. & Rahman, R. & Ibrahim, A. & Grabowskab, A. M. & Alexander, C., (2022) “Histopathological impact of Redox-responsive methacrylamide based micellar nanoparticles on Orthotopic Models of Triple Negative Breast Cancers”, British Journal of Pharmacy 7(2). doi: https://doi.org/10.5920/bjpharm.1173
- EPSRC and University of Nottingham (grant RA26GT)