Histopathological impact of Redox-responsive methacrylamide based micellar nanoparticles on Orthotopic Models of Triple Negative Breast Cancers

Abstract

The therapeutic efficacy of anticancer nanocarriers is highly dependent on their size, shape, targeting ability, and stimuli-responsiveness. Herein, we studied the in vivo therapeutic efficacy of Doxorubicin (Dox) loaded redox responsive micellar-like nanoparticles (MNPs)based on linear 2-hydroxypropyl methacrylamide (HPMA) via histopathological evaluations. The therapeutic efficacy of DOX-loaded micellar-like Nanoparticles significantly improved while the side effects reduced as confirmed by histopathological examinations. H&E and tunnel staining of tumor tissues indicated the higher population of apoptotic tumor cells in both treatment groups containing DOX. These redox responsive crosslinked HPMA-based micellar-like nanoparticles with acceptable therapeutic efficacy and apoptosis induction in cancerous cells proved to be promising nanomedicine for breast cancer chemotherapy.

Keywords

Redox-responsive micellar nanoparticles, Histopathology, apoptosis, Triple negative breast cancer

How to Cite

Mehradnia, F., Moloney, C., Cavanagh, R., Pearce, A. K., Ritchie, A., Clarke, P., Rahman, R., Ibrahim, A., Grabowskab, A. M. & Alexander, C., (2022) “Histopathological impact of Redox-responsive methacrylamide based micellar nanoparticles on Orthotopic Models of Triple Negative Breast Cancers”, British Journal of Pharmacy 7(2). doi: https://doi.org/10.5920/bjpharm.1173

Funding

  • EPSRC and University of Nottingham (grant RA26GT)
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Authors

Fatemeh Mehradnia (University of Nottingham)
Cara Moloney (University of Nottingham)
Robert Cavanagh (University of Nottingham)
Amanda K Pearce (University of Nottingham)
Alison Ritchie (University of Nottingham)
Philip Clarke (University of Nottingham)
Ruman Rahman (University of Nottingham)
Asmaa Ibrahim (University of Nottingham)
Anna M. Grabowskab (University of Nottingham)
Cameron Alexander (University of Nottingham)

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Creative Commons Attribution 4.0

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This article has been peer reviewed.

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