Novel electrospun implants of Sunitinib can depress ex-vivo ocular neovascularization

Abstract

Choroidal neovascularization (CNV) is one of the hallmark symptoms of Wet Age-related Macular Degeneration (wAMD) and DiabeticRetinopathy(DR) which involves formation of neoangiogenic i.e. formation of new abnormal blood vessels emerging from the choroidal blood vessels and protruding through the retinal layer. The current management of wAMD involves intravitreal injections of anti-VEGF such as ranibizumab and aflibercept. We hypothesized the delivery of small molecule anti-angiogenesis agents such as the Sunitinib by episcleral route could be an effective and less challenging solution for the management of choroidal neovascularization. In this research, we have fabricated the sunitinib-loaded implants that are able of sustained the release of drug and possess improved ocular pharmacokinetics with a non-invasive administration. The novel episcleral implants were fabricated by electrospinning and were tested for different physiochemical and well as in-vitro pharmacokinetic properties. Further, these implants were tested for in-vitro biocompatibility and ex-vivo efficacy for the estimation of pharmacodynamic properties.

Keywords

Ocular drug delivery, Episcleral implant, Posterior segment, AMD

How to Cite

Mishra, D., Sigurðsson, H. H., Serro, A. P., Kalesnykas, G., Donnelly, R. F. & Thakur, R. S., (2022) “Novel electrospun implants of Sunitinib can depress ex-vivo ocular neovascularization”, British Journal of Pharmacy 7(2). doi: https://doi.org/10.5920/bjpharm.1174

Funding

  • Horizon 2020 (grant 813440)
383

Views

96

Downloads

Share

Authors

Deepakkumar Mishra (Queens university Belfast)
Hákon Hrafn Sigurðsson (University of Iceland)
Ana Paula Serro (Instituto Superior Técnico)
Giedrius Kalesnykas (Experimentica UAB)
Ryan F Donnelly (Queen's University Belfast)
Raghu Raj Singh Thakur orcid logo (Queens university Belfast)

Download

Issue

Dates

Licence

Creative Commons Attribution 4.0

Competing Interests

Authors have no conflict of interest to declare

Identifiers

Peer Review

This article has been peer reviewed.

File Checksums (MD5)

  • Full text: e5181972bf32d160786db00773836118