Abstract
Age-related macular degeneration (AMD) is a potentially blinding posterior segment disease; inflammatory responses and subretinal drusen formation lead to leaky blood vessels. The current treatment method involves intravitreal injections of anti-VEGF agents, which is highly invasive and requires frequent injections administered by trained personnel. Periocular injections such as trans-/intra-scleral injections would provide a minimally invasive treatment option. The sclera is the outermost protective layer occupying 5/6th of the ocular globe. Owing to its avascular nature and self-healing ability, sclera could be the potential space for the delivery of depot forming long-acting formulations. This project focuses on the development of chitosan grafted poly(n-isopropylacrylamide) (Cs-g-PNIPAAm) gel for the sustained intrascleral delivery of small molecular weight, multiple tyrosine kinase inhibitor Sunitinib malate.
Keywords
Ocular drug delivery, Microneedles, intrascleral
How to Cite
Gade, S. & Larrañeta, E. & Donnelly, R. F. & Vanrell, R. H. & Alvarez Lorenzo, C. I. & Thakur, R. S., (2022) “Development and characterization of injectable depot forming thermoresponsive hydrogel for the sustained intrascleral delivery of Sunitinib”, British Journal of Pharmacy 7(2). doi: https://doi.org/10.5920/bjpharm.1175
Funding
- H2020 Marie Skłodowska-Curie Actions (grant 813440)
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