Dissolution of theophylline from extended-release tablets under cyclic retrograde peristaltic contractions in the Dynamic Colon Model

Abstract

The dynamic colon model isa biorelevant in vitro model of the human proximal colon. In vivo, the largeintestine mixes its contents using peristaltic waves that propagate both forwards(antegrade) and backwards (retrograde). This work studies the dissolutionprofile of theophylline from Uniphyllin Continus 200 mg prolonged releasetablets and the distribution of dissolved theophylline in viscosity-enhancedmedia under the influence of a cyclic retrograde peristaltic contraction. At 16-and 24-hours,  and  theophylline dissolved from the tablet and thefluid inside the mimic intestinal system approached homogeneity.

Keywords

Dynamic colon model, modified release, in vitro models, dissolution testing

How to Cite

O'Farrell, C., Stamatopoulos, K., Simmons, M. J. & Batchelor, H., (2022) “Dissolution of theophylline from extended-release tablets under cyclic retrograde peristaltic contractions in the Dynamic Colon Model”, British Journal of Pharmacy 7(2). doi: https://doi.org/10.5920/bjpharm.1192

Funding

  • AstraZeneca
  • EPSRC Centre for Doctoral Training in Formulation Engineering (grant EP/L015153/1)
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Authors

Connor O'Farrell (University of Birmingham)
Konstantinos Stamatopoulos (GlaxoSmithKline)
Mark J. H. Simmons orcid logo (University of Birmingham)
Hannah Batchelor (Strathclyde)

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Creative Commons Attribution 4.0

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None

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