Abstract
The aim of this project is to assess the anti-bacterial and anti-inflammation properties of a matrix-type silicone elastomer device providing sustained release of DL-lactide (a cyclic ester dimer of lactic acid). Lactide-loaded matrices were prepared by injection molding, and the devices were assessed for of in vitro release, anti-bacterial activity, and anti-inflammatory activity. The devices provided sustained release of lactide/lactic acid over five days and were effective against E. coli and S. aureus. Further, the devices reduced inflammation through activation of the GPR81 receptor via the NF-κB and JAK-STAT signalling pathway. These lactide-releasing silicone elastomer devices could improve clinical outcomes with certain short-term medical devices.
Keywords
Drug delivery system, Multifunctional agents, Bacterial infection, Inflammation
How to Cite
Huang, K., (2023) “Modulation of bacterial infection and inflammation by release of lactide from a silicone elastomer device”, British Journal of Pharmacy 8(2). doi: https://doi.org/10.5920/bjpharm.1344
Funding
191
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