Assembly properties of complex drug delivery systems

Abstract

The interaction of materials within the context of a formulation and its manufacturing process can have a defining impact on a parenteral drug product performance. Therefore, establishment of methodologies to investigate the interactions of drug substance with itself and other components can be a critical aspect of developing a product and understanding its potential failure modes. This paper will discuss some of the methodologies used to investigate assembly properties of different delivery systems, including separation techniques combined with on-line multiple detectors, and nanoscale imaging. Examples where the data are combined with modelling the morphology demonstrate the strength of combining multiple experiments with calculations to provide deeper insight into functionality for e.g. polymeric nanoparticles and drug dendrimer conjugates.

Keywords

Complex characterisation, nanoimaging, nanomedicines, morphology digital twin

How to Cite

Treacher, K. E. & Capomaccio, R. B., (2023) “Assembly properties of complex drug delivery systems”, British Journal of Pharmacy 8(2). doi: https://doi.org/10.5920/bjpharm.1350

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Authors

Kevin Edward Treacher orcid logo (AstraZeneca)
Robin Bruno Capomaccio (AstraZeneca)

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Creative Commons Attribution 4.0

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