Assessment of the Opacity of Titanium Dioxide Free Film Coating Formulations

Abstract

Titanium dioxide (TiO2) is widely used as an excipient in pharmaceutical film coating formulations. In August 2022, the European commission (EC) adopted a ban on the use of TiO2 (E171) as a food additive. There is uncertainty around the implications of this decision on pharmaceutical products, and a potential need to find suitable alternatives to TiO2. In this study, we evaluated the opacity of the different TF film coating systems by assessing the ability of TF film coatings to mask coloured tablet cores at varying weight gainsHPMC-based film coatings containing CaCO3 demonstrated the best covering potential and were positively correlated to the amount of CaCO3 present, while PVA-based film coatings containing CaCO3showed poor coverage, even at 9% weight gain. 

Keywords

TiO2, TiO2-free, film coating, Titanium Dioxide, Opacity

How to Cite

Tee, A., Ogden-Barker, M. & Sproston, K. E., (2023) “Assessment of the Opacity of Titanium Dioxide Free Film Coating Formulations”, British Journal of Pharmacy 8(2). doi: https://doi.org/10.5920/bjpharm.1355

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Authors

Alyson Hui Ling Tee (Pfizer)
Michaela Ogden-Barker (Pfizer)
Kieran Ellis Sproston (Pfizer)

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Creative Commons Attribution 4.0

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This article has been peer reviewed.

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