Phase stability and polymorphism of a new naproxen salt

Abstract

We report on the synthesis and structural characterization of a new naproxen salt. In-situ heating X-ray diffraction experiment allows us to determine the phase stability of the various polymorphic phases. Slow heating rate and repetitive scans strategy were essential to probe all phases in presence. Contrary to previously reported absence of polymorphic forms for naproxen salt, this new salt exhibits one metastable dihydrate form and five anhydrous phases. The crystal structures of all phases were determined using the in-situ X-ray powder diffraction data. 

Keywords

naproxen, polymorphism, phase stability

How to Cite

O'Meara, P., Nénert, G. & Dadivanyan, N., (2023) “Phase stability and polymorphism of a new naproxen salt”, British Journal of Pharmacy 8(2). doi: https://doi.org/10.5920/bjpharm.1370

87

Views

24

Downloads

Share

Authors

Paul O'Meara (Malvern Panalytical)
Gwilherm Nénert (Malvern Panalytical)
Natalia Dadivanyan (Malvern Panalytical)

Download

Issue

Dates

Licence

Creative Commons Attribution 4.0

Identifiers

Peer Review

This article has been peer reviewed.

File Checksums (MD5)

  • Fulltext: 3a035c4fba6d9f28bb0154cc4b2c1065