Dissolution improvement of binary solid dispersions of Carbamazepine using Poly (2-ethyl-2-oxazoline) as the hydrophilic carrier.

Abstract

The aim of this study was to design and evaluate the properties of solid dispersions of carbamazepine (CBZ) using poly (2-ethyl-2-oxazoline) (POX) as the hydrophilic carrier. These binary solid dispersions were prepared at varying drug loadings using the solvent evaporation method. The samples were evaluated for their in vitro dissolution, and solid-state properties. There was over 350% increase in dissolution rate of CBZ in samples containing at least 50% POX. This study concludes that POX is an effective hydrophilic carrier for poorly soluble drugs in solid dispersions. 

Keywords

poly (2-ethyl-2-oxazoline), solid dispersions, dissolution, carbamazepine, solvent evaporation

How to Cite

Adeola, A. O., (2023) “Dissolution improvement of binary solid dispersions of Carbamazepine using Poly (2-ethyl-2-oxazoline) as the hydrophilic carrier.”, British Journal of Pharmacy 8(2). doi: https://doi.org/10.5920/bjpharm.1371

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Adebisi O Adeola orcid logo (University of Huddersfield)

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Creative Commons Attribution 4.0

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This article has been peer reviewed.

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