Evaluation on Stability of Plant-Based Softgels (SeaGel® Technology) versus Gelatine Softgels

Abstract

In this study, a simple model fill formulation of Ibuprofen was encapsulated using either gelatine as the shell-forming material or a plant-based material based on IFF’s SeaGel® technology (noted as SeaGel® softgels).

The result indicates a similar performance at time zero between animal-sourced material (gelatine) and plant-based material (SeaGel®). Importantly, at accelerated conditions, SeaGel® showed no change in performance in disintegration and dissolution over 6 months of stability compared to gelatine which showed significantly slower disintegration and dissolution behaviour than freshly produced gelatine softgels. This work indicates the superior performance of gelatine alternative SeaGel® softgels during stability and long-term performance. 

Keywords

Gelatine, SeaGel®, Ibuprofen, Softgel capsules.

How to Cite

Qadir, M. S., Zhao, J., Putans, B., Watson, T., Evangelista, M., Gillespie, I. & Barnes, J., (2023) “Evaluation on Stability of Plant-Based Softgels (SeaGel® Technology) versus Gelatine Softgels”, British Journal of Pharmacy 8(2). doi: https://doi.org/10.5920/bjpharm.1397

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Authors

Mohammad Siddique Qadir (IFF)
Jin Zhao
Becca Putans
Thomas Watson
Michael Evangelista
Ian Gillespie
Jeremy Barnes

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Creative Commons Attribution 4.0

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