Use of a Suspoemulsion to Improve Bioavailability of a DCS Class IV Compound

Abstract

Enabling formulations are used by the pharmaceutical industry to help improve bioavailability of compounds with low solubility and permeability properties.  Suspoemulsions are a combination strategy of using permeation enhancers in a lipid phase, with drug molecules incorporated as a solid nanosuspension in the aqueous phase to maximise oral exposure.  Here, a suspoemulsion is created by bead milling a classical drug suspension to reach nano size range and combining with a lipid blend of Labrasol ALF and Capmul MCM.  This formulation increased oral bioavailability from 5% to 24%.  The exact mechanism of this improvement is hypothesised but would need further work to establish.

Keywords

Nanosuspension, suspoemulsion, enabling formulations, DCS

How to Cite

Matthews, D., Carr, C., Kale, M. & Bloomfield, D., (2023) “Use of a Suspoemulsion to Improve Bioavailability of a DCS Class IV Compound”, British Journal of Pharmacy 8(2). doi: https://doi.org/10.5920/bjpharm.1408

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Authors

Darren Matthews (Charles River Laboratories)
Charlotte Carr
Madhura Kale
Dawn Bloomfield

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Creative Commons Attribution 4.0

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This article has been peer reviewed.

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