The preparation of HEMA-MPC films for ocular drug delivery

Abstract

There is a need to prolong drug residence time using a biocompatible formulation in the subconjunctival space after surgery to treat glaucoma. Drug releasing discs were prepared with 2-(hydroxyethyl)methacrylate (HEMA) and 2-methacryloyl-oxyethyl phosphorylcholine (MPC). The ratio of bound water (Wb) to free water (Wf) ratio increased from 1:0.3 to 1:6.8 with increasing MPC (0 to 50%, w/w). The optimal balance between water content, SR and mechanical strength were obtained with 10% MPC (w/w) hydrogels. Water-alcohol mixtures were examined to facilitate loading of poorly soluble drugs, and they showed greater hydrogel swelling than either water or alcohol alone. The SR was 1.2 ± 0.02 and 3.3 ± 0.1 for water and water:ethanol (1:1) respectively. HEMA-MPC (10%) discs were loaded with dexamethasone using either water:ethanol (1:1) or methanol alone. Drug release was examined in an outflow rig model that mimics the subconjunctival space in the eye. Dexamethasone loading increased from 0.3 to 1.9 mg/disc when the solvent was changed from water:ethanol (1:1) to methanol with the dexamethasone half-life (t½) increasing from 1.9 to 9.7 days respectively. These encouraging results indicate that HEMA-MPC hydrogels have the potential to sustain the residence time of a drug in the subconjunctival space of the eye.

How to Cite

Al-Sohani A. , Awwad S. , Shaw P. T. & Brocchini S. (2017) “The preparation of HEMA-MPC films for ocular drug delivery”, British Journal of Pharmacy. 2(1). doi: https://doi.org/10.5920/bjpharm.2017.05

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Authors

Athmar Al-Sohani (UCL)
Sahar Awwad (UCL)

Peng T Shaw (National Institute for Health Research)

Steve Brocchini (UCL)

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Creative Commons Attribution 4.0

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This article has been peer reviewed.

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