The Utilisation Of Thermal Methods For The Screening Of Three Component Co-amorphous Systems

Abstract

Indomethacin and piroxicam are known to become amorphous upon rapid cooling after melting. Multiple three-component co-amorphous mixtures have been produced via a melt quench method to evaluate the influence of the third component on stability and physical properties on the co-amorphous mixture of piroxicam and indomethacin. These have then been tested using thermal gravimetric analysis, differential scan calorimetry and hot stage microscopy. Results have confirmed the creation of a three-component co-amorphous system.

Keywords

TGA, DSC, co-amorphous, HSM

How to Cite

D'Angelo A. & Edgar B. & Antonijevic M., (2018) “The Utilisation Of Thermal Methods For The Screening Of Three Component Co-amorphous Systems”, British Journal of Pharmacy 2(2). doi: https://doi.org/10.5920/bjpharm.2017.21

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Authors

Alessandra D'Angelo
Benjamin Edgar

Milan Antonijevic

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Creative Commons Attribution 4.0

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This article has been peer reviewed.

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