Indomethacin and piroxicam are known to become amorphous upon rapid cooling after melting. Multiple three-component co-amorphous mixtures have been produced via a melt quench method to evaluate the influence of the third component on stability and physical properties on the co-amorphous mixture of piroxicam and indomethacin. These have then been tested using thermal gravimetric analysis, differential scan calorimetry and hot stage microscopy. Results have confirmed the creation of a three-component co-amorphous system.
co-amorphous, DSC, TGA, HSM
How to CiteD'Angelo A. , Edgar B. & Antonijevic M. (2018) “The Utilisation Of Thermal Methods For The Screening Of Three Component Co-amorphous Systems”, British Journal of Pharmacy. 2(2). doi: https://doi.org/10.5920/bjpharm.2017.21