The Utilisation Of Thermal Methods For The Screening Of Three Component Co-amorphous Systems

Abstract

Indomethacin and piroxicam are known to become amorphous upon rapid cooling after melting. Multiple three-component co-amorphous mixtures have been produced via a melt quench method to evaluate the influence of the third component on stability and physical properties on the co-amorphous mixture of piroxicam and indomethacin. These have then been tested using thermal gravimetric analysis, differential scan calorimetry and hot stage microscopy. Results have confirmed the creation of a three-component co-amorphous system.

Keywords

co-amorphous, DSC, TGA, HSM

How to Cite

D'Angelo A. , Edgar B. & Antonijevic M. (2018) “The Utilisation Of Thermal Methods For The Screening Of Three Component Co-amorphous Systems”, British Journal of Pharmacy. 2(2). doi: https://doi.org/10.5920/bjpharm.2017.21

43

Views

20

Downloads

Authors

Alessandra D'Angelo
Benjamin Edgar

Milan Antonijevic

Download

Dates

Licence

Creative Commons Attribution 4.0

Peer Review

This article has been peer reviewed.

File Checksums (MD5)

  • : c3bc070639bf6e4c89efde820040ce1a