Multiple three-component co-amorphous systems have been created via a melt- quench method. This has been confirmed by a single glass transition in the individual DSC traces and then reinforced by X-ray diffraction data, which show an absence of crystalline material. ATR-FTIR has also been used to show a change in bonding vibrations between the physical mixtures and co-amorphous samples. The change in bonding vibrations indicates different molecular interactions within the co-amorphous materials.
co-amorphous, DSC, TGA, XRD, ATR-FTIR
How to CiteEdgar B. , D'Angelo A. & Antonjievic M. D. (2018) “The Use Of XRPD And ATR-FTIR In The Screening Of Three Component Co-amorphous Systems Created Via A Melt-Quench Method.”, British Journal of Pharmacy. 2(2). doi: https://doi.org/10.5920/bjpharm.2017.24