Synthesis and evaluation of novel antifungal agents targeted to the plasma membrane H[+]-ATPase

Abstract

A library of dienones were synthesized as candidate antifungal agents. These compounds were screened against Saccharomyces cerevisiae and Candida albicans using macro-broth susceptibility assay. The dienones exhibited a broad range of inhibition against S. cerevisiae (0.2-99%) and C. albicans (0-99%). 3,5-bis(p- trifluoromethylbenzylidene)-1-methyl-piperidine-4-one was identified as the most potent inhibitor of S. cerevisiae. Whereas, the most promising inhibitor of C. albicans was 2,6-bis(pyridine-3ylmethylene)cyclohexan-1-one.

Keywords

antifungal, plasma membrane H+- ATPase, dienone, N-methylpiperidin-4-one

How to Cite

Patel D. V. , Bassin J. P. & Griffiths D. G. (2018) “Synthesis and evaluation of novel antifungal agents targeted to the plasma membrane H[+]-ATPase”, British Journal of Pharmacy. 2(2). doi: https://doi.org/10.5920/bjpharm.2017.28

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Authors

Dhruvnesh V Patel
J Paul Bassin

David G Griffiths

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Creative Commons Attribution 4.0

Peer Review

This article has been peer reviewed.

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