Synthesis and evaluation of pH dependent hydrogels for controlled release of Venlafaxine HCl

Abstract

pH dependent hydrogel formulations of venlafexine HCl were prepared by free radical polymerization method using polyethylene glycol as polymer. Various samples were prepared with varying concentration of polymer, monomer and cross-linker to study their effect on gel swelling, diffusion characteristics and drug release. Swelling was found to be increased with increase in pH. Increase in acrylic acid concentration increases swelling while increase in cross-linker concentration has an opposite effect on swelling. Drug release study was performed in pH 1.2, 5.5 and 7.5 for 12 hours at 37 oC and drug release was found to increase in higher pH. Prepared hydrogel preparations were also characterized by PXRD, TGA, SEM and FTIR.

Keywords

hydrogel, venlafexine, polyethylene, glycol, controlled release

How to Cite

Abbas N. , Amir Ijaz Q. , Hussain A. & Irfan Bukhari N. (2018) “Synthesis and evaluation of pH dependent hydrogels for controlled release of Venlafaxine HCl”, British Journal of Pharmacy. 2(2). doi: https://doi.org/10.5920/bjpharm.2017.30

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Authors

Nasir Abbas
Qazi Amir Ijaz

Amjad Hussain

Nadeem Irfan Bukhari

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Creative Commons Attribution 4.0

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This article has been peer reviewed.

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