Abstract
This work focused on the development of a concentric multi-layered fixed-dose combination via an advanced manufacturing technique, hot-melt co-extrusion. The dosage form was designed to offer differing release behaviour; immediate and sustained release from the coat and core, respectively. Hydrochlorothiazide and losartan potassium were incorporated as anti-hypertensive drugs. Solid-state characterisation revealed that both were transformed into their amorphous forms. In-vitro dissolution testing showed desired release performances offering both immediate and modified release.
Keywords
hypertension, hot-melt co-extrusion, Fixed-dose combinations
How to Cite
Almajaan, A., Healy, A., Jones, D., Gilvary, G., Andrews, G. P., Kelleher, J. F., Li, S., Tian, Y. & Senta-Loys, Z., (2019) “Hot-melt co-extrusion technology as a manufacturing platform for anti-hypertensive fixed-dose combinations”, British Journal of Pharmacy 4(1). doi: https://doi.org/10.5920/bjpharm.596
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