This work focused on the development of a concentric multi-layered fixed-dose combination via an advanced manufacturing technique, hot-melt co-extrusion. The dosage form was designed to offer differing release behaviour; immediate and sustained release from the coat and core, respectively. Hydrochlorothiazide and losartan potassium were incorporated as anti-hypertensive drugs. Solid-state characterisation revealed that both were transformed into their amorphous forms. In-vitro dissolution testing showed desired release performances offering both immediate and modified release.
hypertension, hot-melt co-extrusion, Fixed-dose combinations
How to Cite
Almajaan, A. & Healy, A. & Jones, D. & Gilvary, G. & Andrews, G. P. & Kelleher, J. F. & Li, S. & Tian, Y. & Senta-Loys, Z., (2019) “Hot-melt co-extrusion technology as a manufacturing platform for anti-hypertensive fixed-dose combinations”, British Journal of Pharmacy 4(1). doi: https://doi.org/10.5920/bjpharm.596