Non-adherence to cardiovascular pharmacotherapy in Iraq assessed using 8-items Morisky questionnaire and analysis of dried blood spot samples

Abstract

The study evaluated the non-adherence to selected cardiovascular medications, atenolol, atorvastatin, bisoprolol, diltiazem, lisinopril, simvastatin and valsartan in Iraqi patients by applying a standardized Morisky questionnaire (8-MMAS) and by measuring therapeutic drug concentrations in dried blood spots (DBS) analyzed by liquid chromatography - high resolution mass spectrometry (LC-HRMS). Sixty-nine patients, on continued use of one or more of the selected drugs, were evaluated. The questionnaire showed that 21.7% of participants were non-adherent whereas DBS analysis showed that 49.3% were non-adherent to their medications. No significant correlation between medication non-adherence and gender was detected, but adherence was negatively correlated with the number of medications in the regimen. The 8-items questionnaire was unable to differentiate non-adherence to multiple medications in the prescribed pharmacotherapy regimens. DBS is an alternative to conventional methods to monitor non-adherence objectively. Agreement between the two approaches was weak (Kappa =0.269, p-value 0.05).

Keywords

cardiovascular medication, Non-adherence, dried blood spot, 8-item Morisky questionnaire

How to Cite

Alalaqi, A. D. & Lawson, G. & Obaid, Y. & Tanna, S., (2019) “Non-adherence to cardiovascular pharmacotherapy in Iraq assessed using 8-items Morisky questionnaire and analysis of dried blood spot samples”, British Journal of Pharmacy 4(1). doi: https://doi.org/10.5920/bjpharm.627

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Authors

Ahmed Dayer Alalaqi (De Montfort University)
Graham Lawson (De Montfort University)
Yaseen Obaid (Missan University)
Sangeeta Tanna orcid logo (De Montfort University)

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Creative Commons Attribution 4.0

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This article has been peer reviewed.

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