Design and Evaluation of Time Dependent Delayed-Release Diclofenac Sodium Tablets for Chronopharmaceutical Drug Delivery

Abstract

This research was aimed atformulatingand evaluating time dependent delayed-release diclofenac tablets forchronopharmaceutical drug delivery using press-coating technology. Rapiddisintegrating diclofenac core tablets were initially formulated using the directcompression method. Coats of powdered tragacanth or xanthan gum alone, and incombination in variousmixing ratios of 25:75, 40:60, 50:50 and 75:25 were compressed around the coretablet to form 3- layered tablets. Thepress-coated tablets were evaluated for post compression parameters such asweight variation, crushing strength, friability as well as, swelling index, lagtime and in vitro release studies in three different simulated gastro-intestinalfluids. The result revealed that thecore and compression coated tablet formulations were within the officialspecified limits. The release profile of the press coated tabletsexhibited lag times depending upon the type, amount and polymer combinationratio in the tablet coat. Optimizationwas done using analysis of variance (ANOVA). The optimizedbatch F6 which consisted of 40% xanthan and 60% tragacanth gave a lag time of 6h followed with burst release and complete drug release of 98.51%. Thisresearch shows that press-coated diclofenac tablets with 40:60% xanthan andtragacanth gum coat can be exploited in chronopharmaceutical delivery ofdiclofenac sodium.

 

Keywords

Diclofenac sodium, Press-coated tablets, Chronotherapy, Rheumatoid arthritis.

How to Cite

Sackey J. , Olowosulu A. K. , Abdulsamad A. & Gwari S. (2020) “Design and Evaluation of Time Dependent Delayed-Release Diclofenac Sodium Tablets for Chronopharmaceutical Drug Delivery”, British Journal of Pharmacy. 4(2). doi: https://doi.org/10.5920/bjpharm.655

50

Views

15

Downloads

Authors

Josephine Sackey (Ahmadu Bello University, Zaria. Kaduna state)
Adeniji Kehinde Olowosulu (Ahmadu Bello University, Zaria)

Abdulrahman Abdulsamad (Ahmadu Bello University)

Simon Gwari (Ahmadu Bello University, Zaria)

Download

Dates

Licence

Creative Commons Attribution 4.0

Peer Review

This article has been peer reviewed.

File Checksums (MD5)

  • PDF: e8ebeb0ba28f09ddd37f78ed2b7bee01